Does Imedeen Prime RenewalTMWork? - Complete Review


Read the complete review on the anti-wrinkle supplement Imedeen Prime RenewalTM.

You'll learn what is it for, what's in it, how to use it and how much does it cost.

Also, we're going to compare it with other similar products - especially with the reference in this field, the anti-wrinkle supplements X115® - in order to identify the best skin supplements on the market.

What is it?

What is Imedeen Prime RenewalTM?

Imedeen Prime RenewalTMis an anti-aging food supplement with a day and night tablet formulation.

Imedeen Prime RenewalTMis manufactured by Pfizer Consumer Healthcare, a division of the Pfizer pharmaceutical industry. This is an American company that was born in New York in 1849 and is present in Italy since 1955.

This supplement is indicated as an aid to get rid of the signs that time leaves on our skin as we get older. In fact, its use is recommended from the age of 50 years.

imedeen prime renewal


What ingredients does Imedeen Prime RenewalTMcontain?

This is the ingredients list provided on the package of Imedeen Prime RenewalTM:

"Maltodextrins, fish extract, soybean fibre, vitamin C, anti-caking agent (silicon dioxide, monoglycerides and diglycerides of transfatty acids), modified starch***, white tea extract (Camellia sinensis (L.) Kuntze, leaf), zinc gluconate, glazing agents (methylcellulose, shellac, talc), chamomile extract (Matricaria recutita L., aerial part)***, tomato extract (Lycopersicon esculentum Mill., fruit), grape seed extract (Vitis vinifera L., seed), vitamin E, moistening agent (glycerol), sunflower oil, colouring agents (titanium dioxide, ammonia caramel).

*** only in the tablets for night use.

The product contains soy and fish.

The active ingredients that characterize Imedeen Prime RenewalTMare those highlighted in bold in the list, and they're the same specified in the following table, in which you can see the nutritional value of the product:


  Daily dose (4 tablets) %RDA*
Fish extract (Marine ComplexTM) 315 mg /
White tea extract (Camellia sinensis L. Kuntze, folium) 62 mg /
Chamomile extract (Matricaria chamomilla L., flos)*** 29 mg /
Tomato extract (Solanum lycopersicum L., fructus) 29 mg /
Grape seed extract (Vitis vinifera L., semen) 28 mg /
Vitamin C 60 mg 75
Vitamin E 10 mg 83
Zinc 5 mg 50
* Recommended daily dose.
*** Present only in the tablets for night use.


The remaining ingredients are the so-called "excipients" and their role is to convey the above-mentioned active ingredients and to "keep them together" in order to allow the production of the tablet.

Active substances

Detailed information on the active ingredients contained in Imedeen Prime RenewalTM

In the previous chapter we identified the ingredients of Imedeen Prime RenewalTM.

Now, let's take a closer look at the active substances, in order to comprehend in what way this supplement can help us in the fight against the signs of the aging process.

Marine ComplexTM

The Marine ComplexTM(fish extract) is a special patented compound that consists of proteins and polysaccharides, very similar to the glycosaminoglycans found in the dermis (the intermediate layer of our skin).

Glycosaminoglycans are very important because they promote the maintenance of skin hydration. These substances are capable of binding and retaining large quantities of water, and for this reason they contribute - even though only indirectly - to protect the elasticity and flexibility of our skin.


ViTeaTMis a complex with a patented formulation, that consists of vitamin C and E, white tea extract, tomato extract and grape seed extract. All of these ingredients have antioxidant properties, which is essential to oppose the action of free radicals.

Free radicals are highly reactive chemical species that cause the so-called oxidative stress in the cells of our skin, damaging them and its structure, causing the appearance of wrinkles and other marks.

Free radicals, in fact, are one of the main factors responsible for skin aging.

Chamomile extract

Chamomile extract can be found within a lot of tablets for night use, due to its soothing action. Also, the extract of this plant is well known for its emollient properties.

Vitamin C

Vitamin C has a powerful antioxidant action and it's involved in the formation of new collagen, one of the essential elements - along with glycosaminoglycans and elastic fibers - that constitute the structure of our skin.

Vitamin E

Given its antioxidant action, Vitamin E is useful in protecting skin cells from the dangers of oxidative stress.


Zinc is a fundamental trace element for our skin. It's directly involved in the processes of cell division and DNA synthesis, which makes it a valuable ally for the maintenance of the skin.

In addition, this trace element - along with vitamin C - has a role in the synthesis of new collagen.


Imedeen Prime RenewalTMcomes in a rather simple package containing 120 tablets, enough to complete a month of treatment (30 days).

Inside the box, the tablets for the day are packed two by two in packets with a sun on them; while the tablets for the night are packed - always in twos - inside packets with a moon on them.

Method of use

The recommended daily dose consists of two tablets in the morning (the packet with a sun) and two in the evening (the packet with a moon) along with some water, preferably during meals.

In order to achieve significant results, it's recommended to finish a full treatment of three months (12 weeks).

Clinical Studies

The official site of the product provides the results of a few clinical trials conducted on Imedeen Prime RenewalTMin order to evaluate its effectiveness. These studies found that - as a result of continued use of the product - a significant increase in skin density (both at the dermis and epidermis level, the outer layer of our skin), with an improvement in hydration and an increased collagen production.


Thanks to the tablet formulation and the individual packaging, Imedeen Prime RenewalTMis a very simple and practical product. In fact, all you need is some water and you can take the tablets wherever you want.

Also, since the tablets have to be swallowed without breaking them, you won't have to perceive the "taste" of the product, because, more often than not, the flavors of this type of supplements are certainly not the best.

However, someone could find the fact that you need to take these tablets twice a day not so convenient.


The list price of Imedeen Prime RenewalTMis about 80 euros, but you can also find it online at much lower prices. It's also available on Amazon at a really good price X115 su Amazon

Where to buy it?

Imedeen Prime RenewalTMis available in both pharmacies and para-pharmacies, as well as in several online stores, on the official website of the manufacturer (, on the websites of many pharmacies and para-pharmacies and on Amazon.

Anti-wrinkles in Comparison

Let's dive into the comparison between various anti-wrinkle supplements that we can find on the market.

In order to make things easier, I have listed in the table below the comparison of all the ingredients and the main characteristics (price, size, etc.) of what I consider the best anti-wrinkle supplements: X115® products.

    Imedeen Time Perfection(40+ formula) Imedeen Prime Renewal™(50+ formula) X115®+PLUS2 (intensive formulation) X115® Primary(maintenance formulation)
List price (from the manufacturer's website) Euro 63,9 84,5 62 42
Days of Treatment Euro 30 30 15 15
Cost per day of treatment Euro 2,13 2,82 4,13/3,8* 2,8
Format Tablets Day and night tablets Day Vials Night Sachets Day and night tablets
Active substances
Hydrolyzed marine collagen mg Not present Not present 5.000 200
Marine Complex® (fish extract) mg 210 315 Not present Not present
MSM (methylsulfonylmethane) mg Not present Not present Not present 150
Vitamin C mg 54 60 300 100
Vitamin E mg Not present 10 15 Not present
Resveratrol mg Not present Not present 147 73,5
Alpha-lipoic acid mg Not present Not present 12,5 100
Coenzyme Q10 mg Not present Not present 12,5 Not present
Oleuropein (from olive leaves) mg Not present Not present 0.96 Not present
Ellagic acid (from pomegranate) mg Not present Not present 5 Not present
Hyaluronic acid mg Not present Not present 100 50
Echinacoside from Echinacea angustifolia mg Not present Not present 3,2 3,2
Triterpene derivates from Centella asiatica mg Not present Not present 30 Not present
Biotin mcg Not present Not present 100 Not present
Vitamin B6 mg Not present Not present 2 Not present
Folic acid mcg Not present Not present 100 Not present
Vitamin D3 mcg Not present Not present 2 Not present
Curcumin mg Not present Not present Not present 47,5
Piperine mg Not present Not present Not present 4,75
Polyphenols from Cocoa mg Not present Not present 12 20
Polyphenols from Olive mg Not present Not present 0.96 (as oleuropein) 7.20
White tea extract mg Not present 62 Not present Not present
Chamomile extract mg Not present 29 Not present Not present
Tomato extract mg 29 29 Not present Not present
Grape seed extract mg 28 28 Not present Not present
Zinc mg 4 5 5 5
Copper mg Not present Not present 2 1
* price excluding the commercial value of the free sample of anti-wrinkle cream


Looking at the table it's clear how the X115®+PLUS2 supplement is superior, both in terms of quantity and quality of the ingredients contained.
The same applies to the X115® Primary maintenance formulation, even though the concentrations of active substances are slightly lower than the Plus version (which makes sense, since it's a maintenance formulation).

X115 Collagene

Buy X115®+Plus2 on Amazon or visit the X115 official website

Even though Imedeen Prime RenewalTMis still a good product, it contains concentrations of active substances (such as, for example, vitamins C and E) that are significantly inferior to those in the supplements proposed by X115® supplements. Also, in Imedeen formulation there are no collagen, hyaluronic acid or any ingredient that is able to promote the synthesis of new collagen (such as the extract from Centella asiatica); ingredients that are present in the supplement X115®+PLUS2 .

The rankings

Since I was lucky enough to try all of these supplements, I think I should be able to provide a rating (which is only personal, obviously) on aspects that are very important to me in determining which anti-wrinkle supplement is the best on the market.

In this regard, I created the following table, in which I gave a grade from 1 to 4 for each entry, as explained here:

  • Grade 1 = Insufficient
  • Grade 2 = Sufficient
  • Grade 3 = Good
  • Grade 4 = Excellent
Characteristics X115®+PLUS2 X115® Primary Imedeen Prime RenewalTM Imedeen Time PerfectionTM
Availability 3 3 4 4
Practicality Day Vials: 4 3 3 3
Night Packets: 2
Taste and Flavor 2/3 4 4 4
Quantity of active substances 4 4 2 2
Quality/Price Ratio 4 4 2 2

Again, you can see the superiority of X115® supplements, especially when it comes to the concentration of the active principles and the price performance. In fact, although the price is relatively high compared to other supplements, the amount of active substances contained is definitely higher. Therefore, the price seems more than justifiable.

With regard to the quality/price ratio, I gave a 2 (sufficient) to Imedeen Prime RenewalTM, because the quantity and quality of the active ingredients contained in it - in my opinion - is not sufficient to justify a list price of 84,50 euros. Although, in this regard, it should also be said that there are online discounts and promotions that allow us to buy Imedeen Prime RenewalTMat significantly lower prices; you can see, for example, the deals available on Amazon:

X115 su Amazon

As for the practicality, the tablet format has earned Imedeen Prime RenewalTMa good grade (3), although taking a tablet will never be as practical as taking ready to drink vials.

Full marks for the flavor, since swallowing the whole tablet doesn't perceive any bad tastes.

Buy X115®+Plus2 on Amazon or visit the X115 official website

Pros and Cons

Imedeen Prime RenewalTMpros

  • Practical to use, thanks to the formulation in tablets, wrapped two by two in individual packets for day and night.
  • Good concentrations of antioxidant plant extracts.
  • Without lactose, added sugars, preservatives and artificial flavors.
  • Easily accessible, both in pharmacies and on several online stores.

Imedeen Prime RenewalTMcons

  • Lack of hyaluronic acid and collagen (replaced by marine complexTM, which still has a low concentration).
  • Lack of active substances that can directly promote the synthesis of new collagen (apart from vitamin C).
  • The actual concentrations of antioxidants in the plant extracts (tomato, chamomile, etc.) contained in the product are not specified.
  • Low concentration of antioxidant active ingredients (even though, since the supplement is formulated in tablets, the small size makes it rather difficult to incorporate large amounts of substances).
  • Presence of potential allergens in the formulation (soybean and fish).
  • Quality/price ratio - in my opinion - rather poor.
  • Presence of artificial colourings, like titanium dioxide and ammonia caramel.


Since Imedeen Prime RenewalTMcontains fish extract, its use is not suitable for vegetarians or vegans.

In addition, since the supplement contains soybean fibre and fish extract, its use is contraindicated in subjects with an allergy to these products, and also to molluscs and crustaceans.

My opinion

My opinion about the Imedeen Prime RenewalTMsupplement is good overall. Initially, I must admit I was a bit disappointed, since after a month of treatment I couldn't even see the slightest result on the skin of my face.

As the manufacturer said, in order to get appreciable results, it's recommended that you continue the treatment with Imedeen Prime RenewalTMfor at least 12 weeks. I decided to keep on trying, and I continued to take the supplement and, in the end, my constancy was rewarded.

Already after the second month of treatment I began to notice the first improvements: my skin, in fact, seemed more moisturized and less dry.

Then, at the end of the third month of treatment, the color of my face - which was a bit dull - returned to be bright and my skin texture has also improved.

In conclusion, I think that Imedeen Prime RenewalTMis a discrete product, because my skin has been able to recover its lost moisture and brightness. However, I believe that there are more complementary and more efficient supplements on the market to counter the signs of time. X115 CollageneThis is the case, for example, of the supplements X115®+PLUS2 (shock formulation) and X115® Primary (maintenance formulation), superior in both the quality and quantity of active ingredients and the benefits to the skin.
Buy X115®+Plus2 on Amazon or visit the X115 official website Imedeen Prime renewal
Imedeen Prime renewal compresse giorno notte
Imedeen Prime renewal compresse
Imedeen Prime Renewal Compresse

Are you looking for something exclusive and truly effective?

X115® ACE rediscovers and revolutionises the use of beauty vitamins | A | C | E |

  • Revolutionary effectiveness,
  • Revolutionary bioavailability,
  • Revolutionary safety

Buy X115®ACE on Amazon or visit the X115 official website

Privacy and Cookie Policy